July 20, 2024
In this article, we'll offer you a comprehensive guide and review of the best NMN supplements and address some of the commonly asked questions about NMN.
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As we dive deeper into the realm of health and wellness in 2023, there’s a growing interest in one particular molecule that has gained notable recognition for its role in energy metabolism and longevity: Nicotinamide Mononucleotide, or NMN. Known as a precursor to NAD (nicotinamide adenine dinucleotide), NMN supplements are at the forefront of the conversation about cellular health, energy optimization, and anti-aging.

In this article, we’ll offer you a comprehensive guide and review of the best NMN supplements and address some of the commonly asked questions about NMN. Whether you’re a seasoned supplement user or just starting on your journey, this guide aims to provide you with the knowledge you need to make an informed decision about NMN supplementation. Stay tuned and let’s dive into the world of NMN supplements together!

A quick look at the best NMN Supplements

How We Chose the Best NMN Supplements?

In a market swamped with supplements claiming to be the best, finding reliable NMN supplements that truly deliver on their promises is no easy feat. We took on this challenge with dedication, taking into account several key factors to help identify the top performers in the market.

By considering the quality of ingredients, potency, safety and transparency, customer reviews, and value for money, we have assembled a list of the top NMN supplements of 2023. Whether you’re a frequent user or new to the world of NMN, our guide will help you find a product that suits your needs and delivers on its promises.

Our Reviews for the Best NMN Supplements

1. Wonderfeel Youngr – Altogether the Best NMN Supplement

Wonderfeel Youngr has set a benchmark in the NMN supplement space. With a robust 900mg NMN serving, it provides one of the most potent doses available in the market, ensuring users get a substantial boost to their NAD levels. This potency, coupled with the inclusion of choice antioxidants and sirtuin activators like ergothioneine and resveratrol, equips the body to fight inflammation and oxidative stress efficiently.

The formula’s development, spearheaded by the esteemed NAD expert, Professor Andrew Salzman MD, has been fine-tuned to ensure maximum efficacy. The team’s rigorous research and commitment to excellence are evident in the product’s quality.

What makes Wonderfeel Youngr even more appealing is its cost-effectiveness. Priced at $2.70 per 1g of NMN, it offers great value, ensuring that consumers don’t have to compromise on quality for affordability. This pricing strategy, combined with the positive influx of customer reviews highlighting enhanced energy and mental clarity, firmly cements its top-tier position in the 2023 NMN supplement market.

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2. Elysium Signal – Best Low-Dose NMN Supplement

With 250mg of NMN per serving, Signal is better for those who are very cautious in trying a new supplement, and for those seeking a mild introduction to NAD boosters. Similar to Wonderfeel, this formula also has a sirtuin activation complex, featuring honokiol and viniferin, compounds sourced from nature’s finest – magnolia tree bark and grapevines. These components are handpicked for their potential in supporting mitochondrial health.

Like Wonderfeel, the team behind Elysium is led by a highly respected scientist, Dr. Guarente. While its gentler dose might not be for everyone, consumers can choose to take higher than the recommended dose for better efficacy.

3. Lifeforce Peak NMN – Best NMN Supplement for Berberine Enthusiasts

Peak NMN breaks the mold with its unique formula tailored for holistic health metrics, ranging from metabolic panels to testosterone levels. It offers a low dose of 375mg NMN, and people might want to take two of the recommended serving which of course makes the cost much higher.

What truly differentiates this supplement is its high dose of berberine, an ingredient revered for its multifaceted health benefits, particularly in regulating insulin sensitivity. While the blend with berberine offers a specialized experience, Lifeforce’s transparency about potential ingredient interactions reflects its commitment to user safety. For berberine aficionados, Peak NMN represents a synthesis of NMN and berberine’s combined potential.

4. Elevant Prime – Best NMN Supplement for Immune Support

Elevant Prime offers a nuanced approach to NMN supplementation, claiming to have a unique form of NMN known as NMN-C, which positions it as an efficient NAD precursor.

However, potential users should be aware of the product’s serving size. At 125mg, Elevant Prime offers a comparatively lower dose than some of its competitors. While it’s essential to take an appropriate dosage for optimal benefits, this serving size could be better for those who like to spread their NMN intake throughout the day.

What is NMN? What Does NMN Do In Our Bodies?

Nicotinamide Mononucleotide, known as NMN, is a molecule. When consumed, NMN is absorbed into the bloodstream and converted into NAD within our cells. By effectively raising NAD levels, NMN helps enhance cellular energy production, support DNA repair, modulate immune response, and maintain healthy cellular functions. This not only results in improved vitality but also promotes healthier aging by addressing the root cause of many age-related conditions – declining cellular health.

Benefits of NMN supplements

NMN has become a popular choice among health enthusiasts and researchers alike due to the numerous potential benefits they offer, primarily stemming from their ability to boost NAD levels in the body. Here are some key benefits of taking NMN supplements:

Energy Production
Anti-Aging Effects
Cognitive Health
Cardiovascular Health
Metabolic Health
DNA Repair

Is NMN Safe? Side Effects of NMN Supplements

NMN is generally considered safe for consumption, with no significant adverse effects reported in most scientific studies to date. Research has shown that even at high doses, NMN does not cause serious side effects.

How Much NMN Should I Take Daily?

Dr. David Sinclair, a professor at Harvard Medical School, has mentioned that he takes 1,000mg of NMN daily. Similarly, Dr. Andrew Salzman, a leading researcher in the NAD field, recommends a slightly lower dose of 900mg of NMN daily.

While the precise dosage may vary, both Sinclair and Salzman agree that 900mg-1000mg NMN is the new normal, and this range appears to be safe and potentially more effective, providing the body with a significant supply of this NAD precursor.

Which is Better? NMN vs NR

When it comes to boosting NAD levels, NMN and Nicotinamide Riboside (NR) are two of the most discussed supplements. Both are precursors to NAD and have similar mechanisms, but NMN is thought to be more bioavailable – in other words, it’s more easily utilized by the body.

While NMN is absorbed directly into cells without the need for any conversion, NR must be converted into NMN in the body before it can be utilized, which might make it less effective.

Frequently Asked Questions About NMN Supplements

At what age should I start taking NMN?

NAD levels decrease with age, and this decline typically begins around our late 20s to early 30s and accelerates as we get older. Given this, many experts suggest that individuals could consider starting NMN supplementation in their 30s.

How long does it typically take for NMN supplements to start working?

On a cellular level, NMN is rapidly converted into NAD. However, noticeable health effects might take longer to manifest.

Many users report experiencing increased energy levels and improved overall well-being within the first few weeks of consistent NMN supplementation. However, for the potential long-term benefits of NMN, such as enhanced cognitive function, improved cardiovascular health, and anti-aging effects, it may take several months to a year of consistent use before noticeable changes occur.

Should I Take NMN With or Without Food?

You can take NMN with or without food based on your preference.

What happens when you stop taking NMN?

If you stop taking NMN, the NAD levels in your body are likely to gradually decline back to your baseline pre-supplementation levels. When your NAD levels decrease, you might experience a gradual return of the symptoms or conditions that led you to start NMN supplementation in the first place. This could include reduced energy levels, slower recovery times, and potentially an accelerated aging process at the cellular level.

What NMN supplement does David Sinclair Take?

Dr. David Sinclair has been a vocal advocate for NMN supplements in promoting health and longevity due to their role in increasing NAD levels. Dr. Sinclair has publicly stated that he takes NMN as part of his own personal anti-aging regimen. However, he has not endorsed a specific brand of NMN supplement.

How Can I Increase NMN Levels Naturally?

While direct dietary sources of NMN are limited, you can still adopt certain dietary and lifestyle strategies to help boost NAD levels in your body, indirectly supporting your body’s NMN status.

Maintain a Healthy Diet
Exercise Regularly
Limit Alcohol Consumption
Intermittent Fasting
Limit Sun Exposure

What Foods Contain NMN?

While NMN is found in trace amounts in various foods, it’s important to note that consuming these alone may not significantly increase NMN levels in the body. However, including edamame, broccoli, cucumbers, avocados, tomatoes, and mushrooms in your diet can contribute to a healthy lifestyle overall.

Can I Take NMN With Other Supplements?

Taking NMN with other supplements is generally considered safe and can even be beneficial, depending on the supplements in question. Here are a few supplements that are often taken alongside NMN: Resveratrol, Pterostilbene, Omega-3 Fatty Acids, Coenzyme Q10 (CoQ10) and Vitamin D3.  Remember every individual is different, and what works for one person might not work for another.

Can I Take NMN and NAD Together?

Taking both NMN and NAD is not recommended. NMN is proven to be efficiently brought inside the cells by a special receptor, and then converted to NAD within cells, establishing its superior role as a supplement. On the other hand, from a scientific standpoint, NAD is known to not get into the cells when it’s taken as a supplement. Hence, relying solely on NMN supplementation, or combined with NR, is the clear and more effective choice.

Should I take NAD through IV?

Over the years, there’s been a trend of using IV to introduce large doses of NAD directly into the bloodstream. People claim it boosts metabolism and energy, but only temporarily.

It is important to note that there’s no comprehensive research supporting this method. Using IV might unnaturally spike NAD levels, whereas NMN supplementation offers a consistent increase of NAD levels in the body.

What Is The Best NMN and Resveratrol Supplement?

Resveratrol is a natural compound found in grapes. It’s often paired with NMN as they both have potential anti-aging benefits. Resveratrol is thought to activate certain proteins called sirtuins, which NMN may help facilitate by boosting NAD levels.

Our favorite choice when it comes to the best NMN and resveratrol supplement is Wonderfeel Youngr.

What’s the Best Form – Capsules, Sublingual, or Liposomal NMN

NMN supplements come in various forms, but not all are created equal. Capsules stand out as the most dependable and effective way to ingest NMN.

Liposomal delivery is problematic. It’s not just about stability concerns – liposomes are inherently unstable. They degrade rapidly, leading to a drastically reduced product shelf-life. There’s no research published to date on NMN as a liposomal delivery method.  Both the efficacy and the safety of the liposomal method are highly risky and certainly questionable. Therefore liposomal NMN is not recommended.

Sublingual NMN meant to dissolve under the tongue and bypass the digestive system, is also an unproven method with no research suggesting this being an effective method. Until more research emerges, the traditional capsule form of NMN remains the gold standard for reliability and ease of use.

What Is The Best Time To Take NMN Supplement?

Taking NMN in the morning can align with your body’s natural NAD rhythm and help harness the energy boost during your most active hours.

Does NAD Increase Cancer Risk?

NAD supplements have been found to fight tumors by serving as an energy source for cells. However, the relationship with cancer is complex as cancer cells demand more NAD for their rapid growth. There’s no evidence that NAD supplements cause cancer in healthy cells, but those diagnosed with cancer should be cautious. NAD precursors like NMN and NR may unintentionally support cancer cell growth and should be avoided by those with the disease.

Should I take TMG with NMN?

Many believe that taking NMN supplements requires a concurrent intake of Trimethylglycine (TMG) because NMN supposedly depletes the body’s TMG levels. But is this claim rooted in science?

Not quite. Prof. Andrew Salzman, a Harvard MD and Chief Medical Officer at Wonderfeel, debunks this notion. He assures that our bodies are naturally equipped to maintain adequate TMG levels. After all, TMG is found in everyday foods like beets, quinoa, spinach, and seafood.

Does NMN Reduce Wrinkles?

NMN may contribute to reducing wrinkles and promoting youthful skin. This is largely due to the role of NAD, which NMN helps produce, in maintaining the health and function of cells, including skin cells. Some studies suggest improvements in skin elasticity and wrinkle reduction, but these findings are mostly from animal studies or lab settings. Human studies are still ongoing.

Does NMN reverse gray hair?

Hair graying results from various factors, with a key one being the loss of pigment-producing cells. Although mouse research suggests a link between NAD levels and these cells, more research is needed to confirm if NMN can change hair pigmentation in humans.

How Long Does NMN Stay in Your System?

NMN is quickly absorbed into the bloodstream, peaking within 15 to 30 minutes. While NMN itself doesn’t linger in the body, the effects of increased NAD can have a longer-term impact. Human data on NMN’s longevity in the body is limited, so continuous daily intake is often recommended.

What is NMN Powder?

The powder form of NMN is often chosen for its flexibility in dosing and ease of use. It can be mixed with water or any beverage of your choice for consumption. This flexibility allows for easier adjustment of dosage to meet individual preferences. However, it’s important to consider the powder should be stored in a cool, dark, and dry place to prevent degradation.

Is There a Way to Test NMN Levels?

Testing for levels of NMN itself in the human body is complex. However, it is possible to test NAD levels, which is the main target of NMN supplementation.

Navigating the world of health supplements can be complex, but when it comes to enhancing cellular health and combating aging, the best NMN supplements are emerging as promising options. With careful consideration of quality, dosage, and individual needs, the best NMN supplements can be a valuable addition to a health-conscious lifestyle.



As of 2023, NMN sales are not effectively banned from being sold within the USA. However, the FDA’s recent ruling precluded NMN (nicotinamide mononucleotide) from being included in the definition of a dietary supplement due to a pharmaceutical company investigating NMN as a drug. Major retailers like Amazon decided to remove NMN sales, however, this is not due to safety reasons and the consumer groups are currently fighting back FDA’s decision.

Article paid for by: Wellness Reviews – [email protected]
The news and editorial staff of the Bay Area News Group had no role in this post’s preparation.